The four-episode series is hosted, co-created and executive produced by the actor, who will explore ancient cultures, people and places.
Alongside archaeologists and experts, Fox will delve into such mysteries as Amazon women and the Trojan War.
Investigation Discovery, Travel Channel, American Heroes Channel and Destination America Group President Henry Schleiff said: “When it comes to debunking the myths around some of our greatest historical mysteries, Megan Fox’s passion for discovering the truth is just visceral.
“We are as delighted to have her fresh and unbiased perspective on these events as we are to have Megan in our Travel Channel family.”
Mysteries and Myths with Megan Fox will premiere later this year on Travel Channel.